Police say they began raiding 25 residential and commercial properties around Melbourne at 5am.

“Just heard noises and rumbling and lights were on and screaming, we didn’t really wake up… because its quite normal, its like the third time in a couple of weeks,” neighbour Stephen Van Duynhoven told Sunrise.

An upmarket sedan and Land Rover were also seized from a property at Lyndhurst in Melbourne's south-east.

Assistant commissioner Stephen Fontana says firebombings and shootings are believed to be linked to the Comancheros.

"We believe that they are responsible for up to 21 non-fatal shootings, four arson attacks, serious drug trafficking and firearms-related offences," Assistant Commissioner Fontana said.

"It is anticipated that up to 21 individuals will be interviewed and charged with serious offences including drug trafficking, criminal damage by fire and a number of drive-by shootings causing injury to others."

He said that some people linked to the gang were behind a series of firebomb attacks on strip clubs in the south Melbourne area.

In February last year police suggested a breakaway gang of bikie thugs were behind an explosion that destroyed a Kittens strip club in Caulfield South.

Police said at the time bikies were trying to muscle back in on security contracts they had lost during an internal split 18 months earlier.

Police are expected to reveal further details at a press conference later on Tuesday.